The combination of hydroxypropylmethylcellulose acetate succinate and L-lysine into ternary amorphous solid dispersions of quercetin to enhance its dissolution
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Improving Dissolution of Meloxicam Using Solid Dispersions
Meloxicam is a poorly water soluble non steroidal anti-inflammatory drug and antipyretic agent. The aim of the present work was to investigate the effect of different types of carriers on in vitro dissolution of meloxicam. Meloxicam solid dispersions were prepared by physical mixing, co-grinding and solvent evaporation methods with polyethylene glycol (PEG) 6000. The effect of solubilization by...
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15 صفحه اولAmorphous solid dispersion effects on in vitro solution concentrations of quercetin
academic] Quercetin is a flavonol with potential health benefits including activities against cardiovascular disease, obesity, and oxidative stress. However, the benefits of quercetin are likely limited by poor bioavailability, primarily attributed to its poor aqueous solubility (due to its hydrophobicity and crystallinity) and extensive phase-II metabolism. Improving the apparent solubility of...
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ژورنال
عنوان ژورنال: Carbohydrate Polymer Technologies and Applications
سال: 2021
ISSN: 2666-8939
DOI: 10.1016/j.carpta.2021.100053